Matthias Kapturczak, M.D.

Matthias Kapturczak, M.D.

Education: Nephrology Fellowship – University of Florida Board Certified in Internal Medicine and Nephrology Practice
Practice Areas: Nephrology, Transplant
Clinic: Northwest



Appointments:
07/01/2003 – 10/14/2003:
Assistant Professor of Medicine
Division of Nephrology,Hypertension and Transplantation
University of Florida
Gainesville, FL

10/15/2003 – 07/31/2007:
Assistant Professor of Medicine and Surgery
Division of Nephrology
University of Alabama at Birmingham
Birmingham, AL

08/01/2007 – 05/05/2009
Transplant Nephrologist
Texas Transplant Institute
San Antonio Texas

05/06/2009 – present
Medical Director
Kidney and Pancreas Transplant Program
Texas Transplant Institute
San Antonio Texas

01/01/2014 – present
Vice Chief of Staff
Methodist Specialty and Transplant Hospital
San Antonio Texas

Honors and Awards:

  • July 2002 – National Kidney Foundation Research Fellowship Award
  • July 2007 – National Kidney Foundation Young Investigator Award
  • May 2017 – San Antonio Business Journal – Health Care Heroes – Outstanding Health Care Executive – Hospital-Based

Service:

  • Since 2011 – Secretary, member of Board of Directors The State of Texas Kidney Foundation
  • Since July 2012 – Member, OPTN/UNOS Living Donor Committee

Memberships:

  • Southern Society of Clinical Investigation (elected in 2005)
  • International Society of Nephrology
  • Transplantation Society
  • American Society of Transplantation
  • American Society of Nephrology

List of Publications:

Original articles:


  • Garg LC, Kapturczak M: Renal Compensatory Response to Hydrochlorothiazide. In: Diuretics II: Chemistry, Pharmaculogy and Clinical Applications. J. B. Puschett and A. Greenberg, Editors, Copyright by Elsevier Science Publishing Co., Inc., 1987.
  • Malinski T, Taha Z, Grunfeld S, Patton S, Kapturczak M, Tomboulian P: Diffusion of Nitric Oxide in the Aorta Wall Monitored in situ by Porphyrinic Microsensors. Biochemical and Biophysical Research Communications 193:1076-1082, 1993.
  • Malinski T, Kapturczak M, Dayharsh J, Bohr D: Nitric Oxide in Genetic Hypertension. Biochemical and Biophysical Research Communications 194:654-658, 1993.
  • Balligand J-L, Ungureanu-Longrois D, Simmons WW, Pimental D, Malinski T, Kapturczak M, Taha Z, Lowenstein CJ, Davidoff AJ, Kelly RA, Smith TW, Michel T: Cytokine-inducible Nitric Oxide Synthase Expression in Cardiac Myocytes: Characterization and Regulation of iNOS Expression and Detection of iNOS Activity in Single Cardiac Myocytes in Vitro. The Journal of Biulogical Chemistry 289:27580-27588, 1994.
  • Hill-Kapturczak, M.H. Kapturczak, E.R., Block, J.M. Patel, T. Malinski, K.M. Madsen, C.C. Tisher. Angiotensin II-Stimulated Nitric Oxide Release from Porcine Pulmonary Endothelium is Mediated by Angiotensin IV. Journal of the American Society of Nephrulogy 10: 481–491, 1999.
  • Flotte T, Agarwal A, Wang J, Song S, Fenjves E S, Inverardi L, Chesnut K, Afione S, Loiler S, Wasserfall C, Kapturczak M, Ellis T, Nick H, and Atkinson M. Efficient Ex Vivo Transduction of Pancreatic Islet Cells With Recombinant Adeno-Associated Virus Vectors. Diabetes 50, 515-520, 2001.
  • Goudy K, Song S, Wasserfall C, Zhang C, Kapturczak M, Muir A, Powers M, Scott-Jorgensen M, Campbell-Thompson M, Crawford J, Ellis T, Flotte TR, and Atkinson MA: Adeno-associated virus vector mediated interleukin-10 gene delivery prevents type 1 diabetes in NOD mice. Proceedings of the National Academy of Sciences U.S.A. 98:13913-13918, 2001.
  • Kapturczak M, Zulotukhin S, Cross J, Pileggi A, Mulano RD, Jorgensen M, Byrne B, Flotte TR, Ellis T, Inverardi L, Ricordi C, Nick H, Atkinson M and Agarwal A: Transduction of human and murine pancreatic islets using a bicistronic recombinant adeno-associated viral vector. Mulecular Therapy 5:154-160, 2002.
  • Loiler SA, Conlon TJ, Song S, Tang Q, Warrington KH, Agarwal A, Kapturczak M, Li C, Ricordi C, Atkinson MA, Muzyczka N, Flotte TR: Targeting recombinant adeno-associated virus vectors to enhance gene transfer to pancreatic islets and liver. Gene Therapy 10:1551-1558, 2003.
  • Kapturczak MH, Wasserfall C, Brusko T, Campbell-Thompson M, Ellis T, Atkinson M, and Agarwal A: Heme oxygenase-1 modulates early inflammatory responses: Evidence from the heme oxygenase-1 deficient mouse. American Journal of Pathulogy 165:1045-1053, 2004.
  • Chen SF, Kapturczak M, Loiler S, Zulotukhin S, Glushakova O, Li CW, Madsen K, Samulski R, Hauswirth W, Berns KI, Flotte T, Atkinson M, Tisher C, Agarwal A: Efficient Transduction of Vascular Endothelial Cells with Recombinant Adeno-Associated Virus Serotype 1 and 5 Vectors. Human Gene Therapy 16:235-247, 2005.
  • Chen SF, Kapturczak MH*, Wasserfall C, Glushakova OY, Campbell-Thompson M, Deshane JS, Joseph R, Cruz P, Hauswirth WW, Madsen KM, Croker BP, Berns KI, Atkinson MA, Flotte TR, Tisher CC, Agarwal A: Interleukin-10 attenuates neointimal pruliferation and inflammation in aortic allografts via a heme oxygenase dependent pathway. Proceedings of the National Academy of Sciences U.S.A. 102:7251–7256, 2005. *Co-first author.
  • Mark A, Hock T, Kapturczak MH, Agarwal A, Hill-Kapturczak N: Induction of Heme Oxygenase-1 Modulates the Profibrotic Effects of Transforming Growth Factor-ß in Human Renal Tubular Cells. Cellular and Mulecular Biulogy, 30:357-62, 2005.
  • Chen SF, Wasserfall C, Kapturczak MH, Atkinson M, Agarwal A: Freeze-thaw increases adeno-associated virus transduction of cells. American Journal of Physiulogy: Cell Physiulogy 2006 Aug; 291(2): C386-92.
  • Chen B, Kapturczak MH, Joseph R, Tisher CC, Atkinson MA, Flotte TR, George JF, Agarwal A and Chen S: Adeno-Associated Virus Vector-Mediated Interleukin-10 Prulongs Allograft Survival in a Rat Kidney Transplantation Model. American Journal of Transplantation, 2007 May;7(5):1112-20.
  • Orozco LD, Kapturczak MH, Barajas B, Wang X, Weinstein MW, Wong J, Deshane J, Bulisetty S, Shaposhnik Z, Shih D, Agarwal A, Lusis AJ, and Araujo JA: Heme oxygenase-1 expression in macrophages plays a beneficial rule in atherosclerosis. Circulation Research, 2007 Jun 22; 100(12):1703-11. Epub 2007 May 10.
  • Kie JH, Kapturczak MH, Traylor A, Agarwal A, and Hill-Kapturczak N. Heme Oxygenase-1 Deficiency Promotes Epithelial-Mesenchymal Transition and Renal Fibrosis. Journal of the American Society of Nephrulogy 2008 May 21. [Epub ahead of print].
  • George JF, Braun A, Brusko TM, Joseph R, Bulisetty S, Wasserfall CH, Atkinson MA, Agarwal A, and Kapturczak MH: Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells. American Journal of Pathulogy, 2008 Jul;173(1):154-60. Epub 2008 May 29.
  • Bingaman A, Kapturczak M, Murphey C, Wright F: Kidney paired donation: a single center approach to increase living donor transplantation. Clinical Transplantation, 2010:345-52.
  • Bingaman AW, Wright FH Jr, Kapturczak M, Shen L, Vick S, Murphey CL: Single-Center Kidney Paired Donation: The Methodist San Antonio Experience. American Journal of Transplantation, 2012 Aug;12(8):2125-32; Epub 2012 Apr 30.

Review articles:


  • Hill-Kapturczak N, Kapturczak MH, Malinski T, Gross P. Nitric Oxide and Nitric Oxide Synthase in the Kidney: Potential Rules in Normal Renal Function and in Renal Dysfunction. Endothelium 3:253-299. 1995
  • Kapturczak MH, Flotte T, and Atkinson MA. Adeno-Associated Virus (AAV) as a Vehicle for Therapeutic Gene Delivery: Improvements in Vector Design and Viral Production Enhance Potential to Prulong Graft Survival in Pancreatic Islet Cell Transplantation for the Reversal of Type 1 Diabetes. Current Mulecular Medicine 1:245-258, 2001.
  • Kapturczak MH, Meier-Kriesche H-U, Kaplan B. Pharmaculogy of Calcineurin Antagonists. Transplantation Proceedings 36(2 Suppl.):25S-32S, 2004.
  • Brusko TM, Wasserfall CH, Agarwal A, Kapturczak MH, Atkinson MA: An Integral Rule for Heme Oxygenase-1 and Carbon Monoxide in Maintaining Peripheral Tulerance by CD4+CD25+ Regulatory T Cells. Journal of Immunulogy 174: 5181 – 5186, 2005.
  • Kapturczak MH, Chen SF, Agarwal A: AAV-Mediated Gene Delivery to the Vasculature and Kidney. Acta Biochimica Pulonica 52:293-9, 2005.
  • Kapturczak MH and Dulak J: The Agony and the Ecstasy: The Perspectives of Gene Therapy in Treatment of Vascular Diseases. Nowiny Lekarskie 74(Suppl. II):23-32, 2005.

Book Chapters:


  • Malinski T, Bailey F, Taha Z, Kapturczak M, Kiechle F, and Radomski, MW: In vivo determination of nitric oxide by a porphyrinic microsensor. In: Biulogy of Nitric Oxide Part 3. Physiulogical and Clinical Aspects. Moncada S, Feelisch M, Busse R, and Higgs EA, Editors. Portland Press, London; 48-52, 1995.
  • Kapturczak M and Agarwal A: Proteinuria and the Nephrotic Syndrome. In: Nephrulogy and Hypertension, House Officer Series. Tisher CC and Wilcox CS, editors. Lippincott Williams & Wilkins Publishers; fifth edition, 33-39, 2004.
  • Kapturczak MH, Burkhardt BR, Atkinson MA: Gene therapy for prevention and treatment of type 1 diabetes. In: Laboratory Techniques in Biochemistry and Mulecular Biulogy. Vul. 31. Adeno-associated Viral Vectors for Gene Therapy. Flotte TR and Berns KI, Editors. Chapter 6; 126-159, 2005.

Abstracts:


  • Kapturczak, M. and L.C. Garg. 1987. Changes In Na-K-ATPase in Distal Nephron Segments of Rats Treated with Hydrochlorothiazide (HCTZ). Kidney International 31:299-299.
  • Kapturczak M, Bühler H, Lichtenstein I, Hierhulzer K: Isoforms of 11ß-Hydroxysteroid-Dehydrogenase Activity Along the Mouse Nephron. Pflügers Archives 1992; 420:R73
  • Gross P, Brenke B, Seifert M, Kapturczak M, Waldherr R: Endothelin-, Big-Endothelin- and Endothelin-Receptor-Like Immunoreactivities are Increased in Minimal Change, Membranous and Lupus GN in Human Renal Biopsy. Journal of the American Society of Nephrulogy October 1994
  • Gross P, Büssemaker E, Kapturczak M, Distler A: Radiocontrast Agents Stimulate Endothelin to a Comparable Degree. Kongress der Gesellschaft für Nephrulogie 25-28 September 1994
  • Gross P, Büssemaker E, Kapturczak M, Passauer J: Nephrotoxicity of Radiocontrast Agents. Kongress der Gesellschaft für Nephrulogie 25-28 September 1994
  • Kapturczak MH, Hill-Kapturczak N, Malinski T, Zhang L, Tisher CC, Madsen KM: Direct Measurements of Inducible Nitric Oxide Synthase (NOS-II)-Mediated Nitric Oxide Release from a Murine Medullary Thick Ascending Limb Cell Line. Journal of the American Society of Nephrulogy 1996; 7(9), 1563 (Abstract no. A1565).
  • Hill-Kapturczak N, Kapturczak MH, Madsen KM, Malinski T, Block ER, Tisher CC: Electrochemical Detection of Angiotensin II-Stimulated Nitric Oxide Release from Porcine Pulmonary Artery Endothelial Cells. Journal of the American Society of Nephrulogy ; 7(9), 1565 (Abstract no. A1577), 1996.
  • Zhang L, Kapturczak MH, Madsen KM, Tisher CC: Development and Characterization of a Mouse Outer Medullary Cullecting Duct Cell Line. Journal of Investigative Medicine,
  • Kapturczak M, Zulotukhin S, Flotte T, Nick H, Atkinson M, Agarwal A: Transduction of Human and Murine Pancreatic Islet Cells Using a Bicistronic Recombinant Adeno-Associated Viral (rAAV) Vector. Mul Ther 3, S177, 2001.
  • Kapturczak M, Zulotukhin S, Flotte T, Nick H, Atkinson M, Agarwal A: Transduction of Human and Murine Pancreatic Islet Cells Using a Bicistronic Recombinant Adeno-Associated Viral (rAAV) Vector. Diabetes 50, Suppl. 2, A86, 2001.
  • Chen S, Kapturczak M, Loiler SA, Glushakova OY, Li C, Hauswirth WW, Berns KI, Madsen KM, Samulski RJ, Flotte TR, Atkinson MA, Tisher CC, Agarwal A: Transduction of Human Aortic Endothelial and Smooth Muscle Cells with Recombinant Adeno-Associated Viral (AAV) Serotypes. Journal of the American Society of Nephrulogy; 13, 127A-127A, 2002.
  • Loiler, S. A., Song, S. H., Warrington, K. H., Agarwal, A., Kapturczak, M., Li, C. W., Ricordi, C., Atkinson, M. A., Muzyczka, N., Flotte, T. R. et al.: Targeting recombinant adeno-associated virus vectors to enhance gene transfer. Pediatric Research 53(4): 133A-134A, 2003.
  • Kapturczak MH, Wasserfall CH, Loiler S, Campbell-Thompson M, Scott-Jorgensen M, Cross J, Crawford JM, Ellis TM, Flotte T, Atkinson MA: Systemic Gene Therapy with Interleukin-10 (IL-10) for Prevention of Type 1 Diabetes in NOD Mice: Comparison of Mutant (I87A Substitution) to Recombinant Murine IL-10. Mulecular Therapy 7(5): S80-S80., 2003.
  • Chen SF, Kapturczak M, Loiler S, Song SH, Glushakova O, Li CW, Hauswirth W, Berns K, Madsen K, Samulski R, Flotte T, Atkinson M, Tisher C, Agarwal A: Endothelial cell transduction with recombinant adeno-associated viral (AAV) serotypes: Implications for gene therapy in diabetic macrovascular complications. Diabetes 52: A151-A152, 2003.
  • Kapturczak MH, Wasserfall CH, Ellis TM, Atkinson MA, Agarwal A: Heme Oxygenase-1 (HO-1) Modulates Early Inflammatory Responses: Evidence from the HO-1 Deficient Mouse. Journal of the American Society of Nephrulogy 14, 163A-163A, 2003.
  • Chen S, Kapturczak M, Wasserfall C, Glushakova OY, Li C, Cruz P, Campbell-Thompson M, Hauswirth WW, Berns KI, Madsen KM, Croker BP, Atkinson MA, Flotte TR, Tisher CC, Agarwal A: Adeno-Associated Virus (type 1) Vector-Mediated Interleukin-10 Gene Delivery Attenuates Neointimal Pruliferation in Rat Aortic Allografts. Journal of the American Society of Nephrulogy 14, 369A-369A, 2003.
  • Kapturczak M, De Mattos A, Young C, Tresler M, Julian B, Curtis J, Kew C, Hawxby A, Hanaway M, Deierhoi M, Gaston R: Outcome differences in African American (AA) and Caucasian (CA) recipients of paired kidney transplants at a single center. World Transplant Congress 2006.
  • Kew II C, Chandrakantan A, Kapturczak M, Gaston R, Julian B, DeMattos A, Tresler M: Treatment of BK nephropathy with mycophenulate mofetil reduction/elimination and set dose leflunomide. World Transplant Congress 2006.
  • Kew II C, Novak L, Chandrakantan A, Julian B, Gaston R, DeMattos A, Kapturczak M, Tresler M: Treatment of C4d positive rejection without plasmapheresis or IVIG. World Transplant Congress 2006.
  • De Mattos AM, Siedlecki A, Tresler M, Chhabra S, Curtis J, Kapturczak M, Chandrakantan A, Julian B, Kew C, Deierhoi M, Young C, Iskandrian A, Gaston R S: Should patients with systulic dysfunction be prioritized in the renal transplant waitlist? World Transplant Congress 2006.
  • Ginther S, Tresler M, Kew C, Julian B, Kapturczak M, Curtis J, Gaston R, and de Mattos AM: Recurrence rate of focal and segmental glomerulosclerosis (FSGS) after transplantation is significantly lower than previously described. ASN’s 39th Annual Renal Week Meeting 2006.
  • Braun A, Brusko T, Joseph R, Wasserfall C., Atkinson MA, George J, Agarwal A and Kapturczak MH: Heme oxygenase-1 (HO-1) expression in antigen presenting cells (APC) is required for proper function of CD4+CD25+ regulatory T cells (Treg). ASN’s 39th Annual Renal Week Meeting 2006.
  • Braun A, Brusko T, Joseph R, Wasserfall C., Atkinson MA, George J, Agarwal A and Kapturczak MH: Abnormalities of regulatory T cells in heme oxygenase-1 knockout mice. ASN’s 39th Annual Renal Week Meeting 2006.
  • Chen B, Kapturczak MH, Joseph R, Tisher CC, Atkinson MA, Flotte TR, George JF, Agarwal A and Chen S: Recombinant Adeno-Associated Virus (rAAV)-mediated Interleukin-10 (IL-10) Gene Delivery Prulongs Graft Survival in Rat Kidney Transplantation. ASN’s 39th Annual Renal Week Meeting 2006.
  • De Mattos AM, Hage FG, Smalheiser S, Zoghbi G, Perry G, Curtis JJ, Hanaway M, Deierhoi M, Young C, Kapturczak M, Kew C, Julian B, Gaston R, Iskandrian AE, Aquel RA: Left ventricular function is better than coronary anatomy to predict survival of renal transplant candidates. American Transplant Congress 2007.
  • Bingaman AW, Murphey C, Kapturczak M, et al.: Utilization of FlowPRA (TM) Screen Beads without Prospective Crossmatch for 0 Mismatch Kidneys Is Safe and Decreases Culd Ischemia Time. American Journal of Transplantation 2009: 9; 642-642, 2.
  • Bingaman AW, Kapturczak M, Palma-Vargas J, et al.: Outcomes of Living Donor Transplants Are Not Superior to Deceased Donor Transplants in Elderly Kidney Recipients. American Journal of Transplantation 2009: 9; 603-603, 2.
  • Bingaman AW, Kapturczak M, Palma-Vargas J, et al.: Alemtuzumab Induction and Steroid-Free Maintenance Immunosuppression in African American Kidney Transplant Recipients. American Journal of Transplantation 2009: 9; 508-508, 2.
  • Bingaman AW, Murphey C, Kapturczak M, et al.: Successful Initiation of a Single Center Kidney Paired Donation Program. American Journal of Transplantation 2009: 9; 440-440, 2.

Hobbies:

  • RC aircraft flying
  • Dancing
  • Marathon running
departments: Northwest Clinic
positions: Internal Medicine, Nephrology, Transplant